The holy shrine of Imam Reza, peace be upon him, has received special attention from Iranians since the beginning of the Third century and became a source of blessings and many cultural and civilizational works for the Iranian people. It is necessary to know the cultural works of Motahar Razavi Tomb as a huge religious and cultural complex; Because familiarity with the historical background and the effects of this holy place on people›s lives can be used in the protection, strengthening and current development of the shrine of Hazrat. In this research, the authors have investigated and recognized these cultural works in Iran, from the beginning to the end of the Safavid era, using a descriptive-analytical method. The findings indicate: with the passage of time, the holy shrine of Imam Reza (peace be upon him) has had a significant boom and increase in terms of Islamic and traditional architecture, and on the other hand, the effort to create the well-being of the pilgrims of his eminence during different eras, as one of the important axes of the activities The custodians of Astan Quds Razavi, as well as the residence of scholars and Sadat near the holy shrine of Imam Reza, peace be upon him, have left a significant cultural impact in Iran in the direction of propagating religion and developing and promoting the school of Ahl al-Bayt Infallibility and Purity (peace be upon them).