Depression, as one of the most common psychological disorders, represents a major challenge in the field of global mental health. It is projected to become the leading cause of disability worldwide by 2030. On one hand, psychological approaches such as Cognitive-Behavioral Therapy (CBT), by focusing on the role of negative thoughts and cognitive distortions, have provided effective strategies for treating this disorder. Conversely, religious teachings and the conduct of the Infallible Imams, particularly the Riḍawī conduct, also contain profound cognitive and behavioral strategies for preventing and treating depression. This research aims to conduct a comparative study between the cognitive-behavioral approach and the Riḍawī conduct regarding the treatment of depression, examining the commonalities and contrasts between these two intellectual frameworks. The present study employs a comparative-analytical method with a qualitative approach, conducted through content analysis of religious and psychological texts using library resources and thematic inference. The findings indicate that key concepts of the cognitive-behavioral approach, such as identifying and restructuring negative thoughts, behavioral activation, and the role of the therapist, show significant alignment with the teachings of Riḍawī conduct in areas like self-knowledge, patience, trust in God, contemplation, and remembrance. This correspondence demonstrates the high capacity of Riḍawī conduct for presenting integrative models in the prevention and treatment of depression based on cognitive and .spiritual foundations.