Prevalent economic systems in the world ostensibly pursue the interests of the people; however, in practice, they steer humanity towards a purely materialistic existence. In contrast, the religion of Islam has positioned material aspects alongside, and subordinate to, the primacy of spirituality. This ensures that humanity does not fall behind in the path of attaining perfection and felicity, and can progress in both the spiritual and economic spheres. Spirituality, economics, and the fulfillment of material needs are among the most important subjects in the heavenly teachings of the Ahl al-Bayt (peace be upon them). In this framework, sincerity in action, self-sacrifice, charity, righteous deeds, observance of piety, and the establishment of justice are presented as causes for the increase of wealth and sustenance .The connection between spirituality and economics is profound and inseparable. On the path to acquiring spirituality, economic activity must be directed towards human development and self-refinement so that one may attain salvation and prosperity. In this research, the author aims to examine spirituality and economics as manifested in the conduct and statements of Imam Reza (peace be upon him). The method of this research is analytical-descriptive. Based on the findings, concepts such as justice, work and effort, providing for family expenses, moderation in livelihood, and on the other hand, observing the rights that God has over people, avoiding extravagance, and giving charity in the way of God are among the matters emphasized by His Holiness (peace be upon him).